![]() ![]() The method was validated to meet the College of American Pathology (CAP), Clinical Laboratory Improvement Amendments (CLIA) and New York Department of Health (NYDOH) protocols. Samples underwent solid-phase extraction prior to LC–MS-MS analysis. The positive cutoff was 200 ng/mL for all of the drugs. The set of 100 urine specimens positive by EMIT II (false-positive specimens) was confirmed to be negative by an LC–MS-MS method developed in-house that quantitates AMP, methamphetamine, ethylenedioxyethylamphetamine (MDE, MDEA, Eve), methylenedioxymethamphetamine (MDMA, Ecstasy, XTC) and methylenedioxyamphetamine (MDA). Standards were purchased from Cerilliant (Round Rock, TX, USA). Furthermore, we wanted to investigate whether the false-positive specimens were caused by psychoactive drugs such as synthetic cathinones. TOF technology could enable the identification of unknown compounds by acquiring exact mass and retention time in full-scan mode, which was an added benefit in comparison with LC–MS-MS. We ran this set of 100 false-positive specimens by TOF using a targeted database to identify potential compounds that may have caused the false-positive IA results. ![]() We then evaluated a separate set of 100 specimens that screened positive by IA for AMP and/or MDMA, but did not confirm by LC–MS-MS. We retrospectively evaluated 3,571 specimens screened by the AMP and MDMA EMIT II tests that were reflexed to confirmation testing by LC–MS-MS to determine positivity rates and the percentage of false positives. The aim of this study was to combine accurate mass data from TOF with structural data derived from the literature and CAS to determine whether compounds yet unknown to cross-react with ecstacy (MDMA) or AMP are present in urine samples that were positive by AMP or MDMA IAs, but did not confirm by LC–MS-MS. Large compound databases, such as Chemical Abstracts (CAS), can be searched to associate compounds with similar structural and physical properties with known molecular formulas. While HRMS provides accurate chemical formulas, it provides limited information of the chemical structure for analytes with unknown retention times. Accurate mass data are used to assign a molecular formula to a compound, and analyte retention time helps to correlate molecular formula with known compounds. High-resolution mass spectrometry (HRMS) techniques, such as liquid chromatography time-of-flight (TOF) mass spectrometry, provide accurate mass measurements for identification of compounds present in a specimen. Specifically, amphetamine (AMP) IAs demonstrate broad antibody cross-reactivity with non-targeted compounds that are structurally or physically related to phenethylamines ( 1, 2) ( 12). However, IA drug screens have limited sensitivity and specificity due in part to capture antibody cross-reactivity with structurally similar interfering compounds, producing false-positive results. Urine drug testing is frequently performed by immunoassay (IA) due to ease of use, rapid turn-around time and the ability to screen multiple drug classes. Structural data of targeted antigens can be utilized to correlate HRMS-derived chemical formulas with structural analogs. Urine analysis by HRMS correlates accurate mass with chemical formulae, but provides little information regarding compound structure. The chemical formulas and exact masses of 145 structures (of 20 chemical formulas) were compared against masses identified by TOF. Compounds known to have cross-reactivity with the IAs were identified in the structure-based search. Chemical formulas and exact masses of 145 structures were then compared against masses identified by TOF. Separately, SciFinder (Chemical Abstracts) was used as an in silico structure search to generate a library of compounds that are known to cross-react with AMP/MDMA IAs. Hundred false-positive IA specimens for AMP and/or MDMA were analyzed by an Agilent 6230 time-of-flight (TOF) mass spectrometer. We employed two techniques, high-resolution mass spectrometry (HRMS) and an in silico structure search, to identify compounds likely to cause false-positive results. Some amphetamine (AMP) and ecstacy (MDMA) urine immunoassay (IA) kits are prone to false-positive results due to poor specificity of the antibody. ![]()
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![]() Data and improved population health: Using MedPar and other publicly available data to benchmark against other healthcare organizations, hospitals can identify opportunities for clinical and financial improvement in the management of specific patient populations.Data also can be harnessed to help healthcare organizations standardize and streamline care across individual physicians or entire hospitals or clinics. Data and quality care: Providers can use real-time data to help clinicians make decisions about patient care, as well as improve future patient care through the capture and analysis of patient satisfaction surveys.Keep reading for the different ways analytics can give providers-and payers-the tools they need to make improvements and achieve the healthcare triple aim. As cost, quality and outcomes become the focus of today’s healthcare landscape, health IT, with its ability to harness data through analytics, is emerging as an obvious player. It was a term dubbed by the Institute for Healthcare Improvement in 2008 when it created a framework for optimizing health system performance by simultaneously focusing on the health of a population, the experience of care for individuals within that population and the per capita cost of providing that care.įast-forward a decade later and it’s not just a good way to operate, but a necessary one, too, as healthcare reform is forcing the move away from fee-for-service and toward value-based care. To learn more about the IHI Triple Aim, visit For more information on Triple Aim, click on the video below to see what PENTAX Medical is doing.The triple aim of healthcare is to achieve good quality of care, low costs and improved population health. Every healthcare provider as well as the patient has an equal stake and role in patient safety and achieving the three elements of the Triple Aim. These six dimensions are fundamental to building both high reliability and safe healthcare delivery networks, both inpatient and outpatient. In addition to the Institute for Healthcare Improvement’s Triple Aim framework, the Institute for Medicine (IOM) for also developed dimensions for safer patient care: ![]() ![]() ![]() Simple efforts to improve patient satisfaction, such as more efficient discharge planning and interactive patient education, can have significant positive impacts on HCAHPS scores, which directly impacts facility reimbursement. sedation), post-procedure pain, and communication to the patient from the healthcare provider team. Patient satisfaction can be directly influenced by multiple factors including patient wait times, comfort level during procedures (i.e. The HCAHPS is the first and only nationally, standardized reporting system specific to the patient’s perspective of their healthcare delivery. Patient satisfaction is a critical element of improving healthcare quality and outcomes and is measured by the Centers for Medicare and Medicaid Services (CMS) Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey. Reducing the per capita cost of healthcare.Improving the health of the population served.Improving the patient experience of care (this includes both quality and satisfaction).It is essentially a simple framework that details three core elements of improving healthcare system performance and quality. The Triple Aim was developed by leading experts at the Institute for Healthcare Improvement (IHI). Many healthcare professionals have heard the term “Triple Aim” tossed around, but are sometimes unsure of the true meaning of the concept and specifically how it applies directly to their respective role. ![]() ![]() Wget -O /mnt/user/appdata/crypto-exchanges-gateway/config.json Įdit config.json and change 127.0.0.1 to 0.0.0.0.ĬryptPad is the Zero Knowledge realtime collaborative editor.mkdir -p /mnt/user/appdata/cryptpad/config wget -O /mnt/user/appdata/cryptpad/config/config.js This project cannot be considered in any way as trading advice. ![]() Self-hosted website change detection monitoring.ĬloudBeaver is a free and open source web-based database management tool.Īn open source, privacy focused discussion platform.Ĭonvos is the simplest way to use IRC and it is always online Blue Iris is affordable and powerful enough to safeguard your family, property and valuables at home or work. It adds and supersedes several features in Airsonic.Īpprise API - Push Notifications that work with just about every platform!īackupPC is a high-performance, enterprise-grade system for backing up Linux, Windows and macOS PCs and laptops to a server's disk.īlue Iris video security software runs on a PC and can provide recording and playback for up to 64 IP network cameras or webcams. Docker Image - One Image endless BotsĪirsonic-Advanced is a more modern implementation of the Airsonic fork with several key performance and feature enhancements. Community Applications moderates the entries so that any incompatible / non-functional apps will not appear (and it looks a lot better also ![]() ![]() The best way to install applications on unRaid is with the Community Applications plugin UnRaid App List DID YOU KNOW THAT YOU CAN HELP FIGHT THE SPREAD OF COVID-19 BY SIMPLY INSTALLING EITHER THE BOINC OR FOLDING AT HOME APPLICATIONS? WE ARE ALL IN THIS TOGETHER, AND EVERY LITTLE BIT HELPS US ALL - Thank You, Andrew Zawadzki ![]() ![]() ![]() This will copy all the selected emails to your Office 365 account.Click Copy and then select your Office 365 account.Select the MBOX file messages and right-click on them.Step 4: Transfer Gmail MBOX File Emails to Office 365 Once the file is uploaded, you can access the emails of MBOX file.Right-click on Local Folders and go to ImportExportTools NG > Import MBOX File.Select ImportExportTools NG from the list and then click the +Add button.Type ImportExportTools in the search box.Select the Add-ons option from the Tools menu.Press the Alt key while the email client is active.Use the ImportExportTools NG add-on to import MBOX into Thunderbird.Step 3: Import Gmail MBOX file into Thunderbird Select Complete and Log In to verify your credentials.Outgoing: SMTP, server name –, port – 587, SSL – STARTTLS, Oauth2 authentication, username – your O365 email id Incoming: IMAP, server name –, port – 993, SSL – SSL/TLS, Oauth2 authentication, username – your O365 email id Select the Manual Configuration tab and make the following changes:.Now, visit the Mail Account Setup Wizard, enter your full name, Office 365 email address, and password.If you already have an account, you can skip establishing a new account. Thunderbird is available for free on the Mozilla website.To set up Thunderbird and configure it for your Office 365 account, follow the below steps: Step 2: Set up Thunderbird and Configure it for Office 365 Once the procedure is complete, the data is saved in a ZIP file on your computer.Click on “Add to Drive” and then click the "Create Export" button.Select the items you wish to import and proceed by clicking "Next.".Select Mail to download from the provided list.Step 1: Use Google Takeout to Export Gmail Data to MBOXįirst, export the data from Gmail to MBOX file using Google Takeout. Here’s the detailed step-by-step procedure. Finally, transfer your Gmail MBOX emails to Office 365. Then, you need to download Thunderbird – a free email client that supports MBOX files and configure it for Office 365. Workaround to Migrate Gmail to Office 365Īs there is no direct way to migrate Gmail data to Office 365, you need to first export the Gmail emails to MBOX file using the Google Takeout – a free service offered by Google to export data from Gmail, YouTube and other applications. However, there is no direct way to just migrate from Gmail to Office 365. One Note, Outlook, Skype for Business, and many more Microsoft applications are included in the Office 365 software suite.ĭue to these and other benefits, users plan to migrate from Gmail to Office 365.Extra storage space is available with a paid Microsoft Office 365 online subscription.Office 365 accounts are managed centrally by those in charge. ![]() It has cutting-edge protection and safeguards mechanisms.There are various advantages of using Office 365, such as: On the other hand, Office 365 is a cloud-based service offered by Microsoft. ![]() ![]() Gmail users can access Google's free cloud services, including email, contacts, calendars, videos, files, and more. Today, nearly everyone uses Gmail as a primary tool of email communication. ![]() ![]() This is certainly not the only possible range it is the range that we have deduced from observations of our sample. The history of this concept and a more extensive explanation of the reasoning are detailed by Curran-Everett ( Curran-Everett, 2009b).įigure 3A shows the difference between the actual means we found, and also the range of differences between means that could occur, entirely by chance, on 95% of occasions. We decide arbitrarily, but in common with many other researchers, that we will be willing to conclude that training has an effect if the probability of seeing this observed difference in the means, or a more extreme difference, is less than 5%, if truly the jumps came from the same population. This method of finding a shift in a set of variable's values is analogous to picking out a signal from background noise – which depends on the signal to noise ratio. We compute this using a formula that relates the sizes of the differences between the values to the scatter of the values. We calculate the probability (or P-value) of finding the observed difference between the mean distances jumped by the two groups, or something more extreme, given that they are taken from the same population. If we propose that the mean values have been calculated from samples taken from the same population, any difference we do find between the mean values would be the consequence of chance alone. ![]() That is, we assume that training has no effect on the mean distance jumped. We can examine whether there is indeed a training effect, by first assuming the opposite. The effects of training a random sample of frogs. However, because the values in the 2500 frogs entered in the competition show quite a scatter, it is not likely that a small random sample will give us a mean that is quite the same as the mean of another random group. These sample mean values seem to be different and we suspect that the training could have had a positive effect. As we suggested in a previous article ( Drummond and Vowler, 2011), we will display the results by plotting individual data, and calculate the mean distance jumped by each group ( Figure 2). You start with two groups of 20 frogs, both drawn at random from the competitors registered for the 1986 frog jumping competition: one group is left alone, you train the others, and then you see how far they all can jump. This is perhaps the most frequent question in biology that is subjected to statistical analysis: does a treatment make a difference? In fact, the standard test used is not posed in this way. You might even want to place a bet on them, like Jim Smiley. You would like to know if this training makes them do substantially better when they enter the competition. How effective is training frogs to jump? Would you bet on the result? Suppose you were able to take some frogs, at random, from these contestants, and train them to jump well. This distribution is a frequent pattern in biology, and can be described mathematically. ![]() ![]() This frequency function is ‘bell’-shaped, and is known as the Normal or Gaussian distribution. ![]() The imaginary data come from a commonly encountered distribution and are summarized in a frequency curve (right side of Figure 1). On the right, the distribution of these distances is summarized. The square marks the record breaking jump of Rosie the Ribeter, and the circle is the runner-up, Jumping Jack Flash. The distance jumped by each contestant is shown on the left. ![]() ![]() ![]() 19 Inches High, Holds 1 Gallon of Water Stainless Steel Bowl and Lid Comes with Bowl, Lid, Gasket, FingerValve, Pressure Plug Read Product Description below to get correct size and for full information Are you tired of all the water trails to all parts of your house? The Slopper Stopper Dripless Water Bowl was designed to eliminate the constant mess dogs and cats make at their water bowl. He never did it again, he just wanted me to know that as the smartest dog, a border collie, he could.įor Multiple Small Breed Dogs 0-20 Lbs. I swear he turned around and grinned at me for his accomplishment. ![]() Until he was able to flip it up against the wall and then paw at it and nudge it upside down finally. Once in the corner he got leverage to slightly lift the edge of the bowl off the floor, and after some tries he figured how to push it up and get his nose under more of it. He kept nudging it with his snout and inch by inch moved it into an inside corner of the walls. Then being a border collie he figured something out. So we used it for a week and although he tried, the bowl did not flip over due to how it is weighted. So PC Richard started carrying this $50 dogfood bowl which I first thought was a little much.īut hey if it doesn’t flip over, then to me it’s worth it. At the time my border collie puppy was 6 mos old and kept flipping his food bowl over any and every bowl. ![]() Just bought one for my new puppy, a border collie. ![]() ![]() Part of the appeal also seems to be the scavenger hunt to find certain flavors, especially quirky seasonal ones. It’s a big jump from the company’s early days when Nightingale was known for collaborations with local breweries (think gingerbread stout). “It actually makes the banana ice cream just more rich.” They also recently partnered with hotel heirless/influencer/fashion designer Nicky Hilton Rothschild for Nicky’s Blondie with vanilla honeycomb ice cream and golden graham cookies. “You don’t taste mayonnaise, but you get the creaminess and just a little tang at the end,” Pollack says. In July, it teamed up with Duke’s Mayonnaise for a banana-mayo ice cream sandwich. The latest viral moment might also have to do with some of Nightingale’s off-the-wall, limited-edition collabs. ![]() Nightingale Ice Cream Sandwiches come in 14 signature flavors plus limited-edition specials. (Find a map of all the retailers carrying the products here.) Despite growing from a 200-square-foot restaurant kitchen to a 10,000-square-foot production facility in Richmond, the ice cream is still churned in small batches and cookies are baked by hand. ![]() Meanwhile, Nightingale’s bite-sized brand, Chomp, launched in Walmarts at the end of March. Pollack suggests that part of the recent hype might have to do with Nightingale’s latest expansion push: The sandwiches became available in The Fresh Market locations across the country in April. ![]() They’re sold in gourmet shops, independent grocers, and other small chains up and down the East Coast, and shipped nationally via a partnership with online purveyor Goldbelly. The operation has exploded over the past six years, from producing 100 sandwiches per week to 15,000 per day. ![]() ![]() ![]() Axel, Blaze and their mates will start a very special deranged training with the help of Dr. The fight continues in Wood Oak City! After the events of Streets Of Rage 4, our heroes wanted to prepare themselves for future threats. We have the full rundown of what's in the DLC along with the latest trailer for you here. What's more, a new physical version of the game will this content included on the cartridge is also now available for pre-order through Merge Games, and will launch on September 28th. ![]() We now know that this new DLC will launch on July 15th for $8 on PS4, Nintendo Switch, Xbox One, and PC via Steam, GOG, and the Windows Store. ![]() X Nightmare DLC be made available for Streets Of Rage 4. Lastly, there is a new Mania+ difficulty option for players who have mastered Streets of Rage and want to experience the maximum challenge the thugs of Wood Oak City can dish out.Dotemu revealed this week when we'll be seeing the Mr. There are color palette options to alter the appearance of characters along with various balancing and refinement changes. This update includes a training mode for players who want to master each of the characters. X Nightmare DLC is available for $7.99 on PC and console, but those who opt not to purchase it will also find new additions to Streets of Rage 4 in a free update that launches today. These bonuses could be phantom fighters to assist or adding poison or fire to weapons to name a few of the assists. What makes it more interesting is after each level the player can choose a bonus to help them in the successive floors. It’s a fun challenge mode and a good way to familiarize oneself with the move sets of each of the new characters. Survival mode is the typical progressive, see how many rounds of enemies you can survive on a single life. The new Survival mode is essentially what one would expect from such a mode but it comes with a twist. The longstanding rivalry between him and Axel makes him an odd choice for recruitment but he did have cool moves when we fought him so having him on the team isn’t a bad thing. X he seems to have found a new path in this latest entry. ![]() Shiva was a boss in Streets of Rage 2, 3 and 4, but instead of being a henchman of Mr. There were some… complications… and he ends up being a boss in Streets of Rage 4, but with the DLC he’s back on the side he belongs. The enormous wrestler Max Thunder was introduced in Streets of Rage 2 as one of the playable characters and Axel Stone’s friend. She is a formidable special forces cop when players fights against her, and she remains just as deadly when she goes against Mr, and Ms. Estel makes her debut in Streets of Rage 4 as the boss of stage 4 and 7. The three new playable characters are Estel Aguirre, Max Thunder and Shive. X Nightmare introduces three new playable characters to the roster, new moves and weapons, a new Survival mode and new music from Tee Lopes, who has also provided music to Sonic Mania, League of Legends and the upcoming Teenage Mutant Ninja Turtles: Shredder’s Revenge. Streets of Rage 4 was one of the best brawlers of 2020 and today it becomes even better with the Mr. ![]() ![]() Stars are awarded to players based on the number of gadgets used as opposed to the amount of time that is taken to complete the level. Bonus levels are acquired through the acquisition of stars. Players complete a group of levels while being awarded stars based on the performance in the level. The level progression in Feed Me Oil is pretty standard to previous games released by Chillingo. ![]() Players are required to utilize a number items such as magnets, pinwheels, and fans in order to get the liquid gold into the mouths of the beasts. The behemoth monsters will eat all of the oil that comes to them but first the oil must be delivered directly to their mouth due to their inability to move. The only way for a clean tomorrow is to feed the oil to large oil-eating beasts. The game revolves around the storyline that a large oil pipe has broken and there is crude oil spilling throughout the land. Feed Me Oil is a game that is both visually appealing and challenging to the user and offers the avid iPhone gamer something that few other applications can. ![]() As the developers of the highly acclaimed Angry Birds app, Chillingo has recently released Feed Me Oil for the iOS audience. In a world dominated by iPhone applications and games, Chillingo stands apart from many app developers in that they always leave their customers happy with the final product. ![]() ![]() ![]() Neither do armadillo babies resemble a dog’s pup in any manner. ![]() Just because the armadillo babies are called pup doesn’t mean that they have got anything to do with dogs. Sounds quite difficult to believe huh? But yeah, armadillo babies are called pups. Whereas, some say that this might be due to an evolutionary quirk that somehow got into the genes of female armadillos! And there have been two schools of thought regarding this.Ī group of biologists says that this is done in order to avoid the risk of interbreeding among siblings. Scientists haven’t yet clearly identified as to why this happens. These fertilized eggs always break into four identical zygotes which yield quadruplets. It was found out that all the armadillo babies are born from a single fertilized egg and not from different eggs as that in the case of other mammals. ![]() The striking factor when it comes to armadillos is that they always give birth to identical quadruples and they always have the same gender.Īrmadillos giving birth to identical quadruples have been a matter of interest for most biologists and they did a lot of research trying to debunk the mystery. Whereas, the giant armadillos have a gestation period of about months. For instance, the large hairy armadillos have a gestation period of about 2 months. The gestation period may vary with the species of armadillos. Though armadillos have an unearthly appearance, they still are mammals and they give birth to their young.Īrmadillos have a gestation period of around 2 to 4 months. 9 Less Known Facts About Baby Armadillos Armadillos do not lay eggs ![]() |
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